The one-car crash happened just before 1 a.m. Thursday in the southbound lanes.
Police say there were four people in the car. One, identified as 17-year-old Ali Alghaithi, of Manhattan, was found outside the vehicle and was pronounced dead at the scene.
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Three others were taken by ambulance to Jacobi Medical Center in the Bronx, where 17-year-old Abdlwahab (Abdul) Abushaar later died of his injuries.
The 18-year-old driver and a 15-year-old passenger remain hospitalized.
It's unclear exactly where the group was coming from, as they had visited friends in different locations, at one point making a stop in Queens.
Two of the teens worked together at a cell phone store in Upper Manhattan, of them close friends since childhood, bound by their Yemeni heritage.
Investigators are working to determine what led to the crash.
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