The 23-year-old victim was shot in the chest near West 125th Street and Frederick Douglass Boulevard around 3:45 p.m.
He was taken to Mount Sinai St. Lue's in critical condition where he was later pronounced dead.
The suspect ran away from the scene and was last seen wearing a bubble jacket and sweatpants.
The details surrounding the shooting were not yet known.
No arrests have been made at this time and the investigation remains ongoing.
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