It happened Saturday morning on East 34th Street.
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Surveillance video shows the man filling a bag with Gatorade and other items before trying to leave the store.
Investigators say when a security guard intervened, the suspect tried to stab him with a hypodermic needle then ran off.
The security guard suffered pain to his left hand but refused medical attention.
Police are asking for the public's help tracking down the suspect.
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Call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782). You can also submit tips by visiting the CrimeStoppers website at crimestoppers.nypdonline.org or by messaging on Twitter @NYPDTips.
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