The 34-year-old man was believed to be sleeping at the time of the stabbing inside Hudson River Greenway Park near West Street and Christopher Street.
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Police say he had a stab wound to his torso.
The victim was taken to NYC Health & Hospitals/Bellevue where he was pronounced dead.
It's not yet known what led to the man being stabbed.
So far there are no arrests and the investigation is ongoing.
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The victim's identity has not yet been released pending family notification.
Anyone with information in regard to this incident is asked to call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782).
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