The team said it was notified of the positive tests overnight and the players were immediately told to self-isolate.
The players were not identified.
The team said the contact tracing process is underway.
The Giants' office was already closed Friday because the team is on a bye week.
The team said players and coaches will resume work on Monday with adjusted schedules.
The Giants are coming off their first two-game winning streak under rookie coach Joe Judge.
The team is just 3-7, but they still have a shot at winning the NFC East.
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