New York City officials say these most recent patients did not travel, suggesting person-to-person transmission is occurring in the city.
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The cases are in males ages 27 to 50.
"Anyone can get and spread monkeypox," the city said in its latest health advisory. "The current cases are primarily spreading among men who have sex with men, so this group is now at greater risk of exposure."
Additionally, a state official says one probable case of monkeypox has been identified in Westchester County. There has been one probably case previously reported in Sullivan County.
Monkeypox is harder to contract than COVID, as it requires close contact or the sharing of bodily fluid.
The symptoms of the rare virus include fever and rash, muscle aches, and chills.
"Any New Yorker who feels sick should stay home and contact their provider if they notice sores or lesions," the New York City Department of Health and Mental Hygiene said.
New York City investigated its first possible case of monkeypox in the area late last month.
The World Health Organization is assessing whether the current monkeypox outbreaks in several countries presents a public health emergency of international concern.
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Worldwide, it is deadly in between 3% to 6% of cases, though the death rate is less than 1% in areas with quality healthcare.
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