The shooting happened just after 5:45 a.m. in an alley on West 206th Street.
Police say the man was taken to YC Health and Hospitals/Harlem in critical condition where he later died from his injuries.
Officers were canvassing hospitals for a possible second victim.
No arrests have been made and the victim's identity has not yet been released.
Separately, but also in Inwood, a man is recovering after being stabbed on a subway train.
The 30-year-old was stabbed in the arm on a northbound A train around 5:45 a.m.
He was treated at Harlem Hospital. The suspect was last seen fleeing the Dyckman Street subway station.
ALSO READ: Sinkhole nearly swallows car in Brooklyn
Sinkhole nearly swallows car in Bath Beach following water main break
----------
* Get Eyewitness News Delivered
* More New York City news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube