The body of 38-year-old Denisse Oleas-Arancibia of Queens was discovered in the SoHo 54 Hotel last Thursday under a blanket next to a bloody iron.
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A medical examiner ruled her death as a homicide, as an autopsy determined she died of blunt head trauma and compression to her neck.
Investigators believe the man put her leggings on because his own jeans, which police found in the room, had blood on them.
Along with finding his pants in her room, detectives have recovered an extensive amount of surveillance video of the man, and they are attempting to locate him.
Oleas-Arancibia was said to have been known to check into the hotel periodically.
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The victim's son filed a missing person's report when she did not return home.
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