"Cancer is the second leading cause of death in the U.S. and the leading cause in Canada," Witherspoon said in a statement. "I'm proud to highlight the amazing doctors and scientists of Stand Up to Cancer who work tirelessly on important cancer research, innovative treatments and much needed patient care."
"Having lost my father to this disease, it is a privilege for us to continue to support the important work of Stand Up to Cancer as co-producers of the telecast," Toth added.
"Black-ish" star Anthony Anderson, Ken Jeong, Tran Ho and Sofia Vergara will co-host the telecast, which will also feature performances by Grammy-winning artists Common and Brittany Howard.
Vergara, a survivor of thyroid cancer, noted that the most important part of her cancer diagnosis was catching it early: "With all the complications and delays the pandemic has caused, it is more important than ever to support Stand Up To Cancer, so others have the resources they need for early detection."
"When my father died of cancer, it gave me new awareness and purpose towards healing," Common said. "I carry his spirit with me in everything I do, and I know he'll be with me on this special night with Stand Up to Cancer."
The telecast marks Stand Up to Cancer's seventh biennial roadblock televised fundraising special. Additional celebrity guests and performers will be announced at a later date.
You can watch the 2021 Stand Up to Cancer fundraising event Sat., Aug. 21, at 8 p.m. ET/PT | 7 p.m. CT on ABC.