It happened just before midnight Tuesday at Country Club Road in the Pelham Bay section of the Bronx.
The driver and a passenger in a southbound vehicle were killed when it struck a utility pole, sending it out of control.
Breaking overnight — 2 people dead in a fiery high speed crash on the Bruckner Expresseay just south of Country Club Rd. Speeding car flipped into oncoming traffic and burst into flames. All lanes closed. #abc7NY pic.twitter.com/If59tLSiYV— Derick Waller (@wallerABC7) July 21, 2020
The vehicle flipped into the northbound lanes, where it struck three other vehicle and burst into flames.
Five people in the other vehicles survived the crash.
WATCH: Fiery fatal crash creates traffic mess in Bronx
Two were taken to St Banabas Hospital with minor injuries. Three others refused medical treatment.
One man at the scene said his 18-year-old nephew and girlfriend were killed in the crash.
"He liked racing and stuff," the man told Eyewitness News. "So I guess he raced right here. And he crashed, it was a four-car crash. Him and his girlfriend passed away, they died. It was a big fire.
The man said his nephew liked to race for money.
"I want to tell the young people, don't race," he said. "It's not cool."
As the NYPD highway patrol investigated Tuesday morning, neighbors told Eyewitness News racing is a problem not just on the highway, but also on side streets.
The names of the victims have not yet been released.
The Bruckner Expressway was closed in both directions for hours approaching Country Club Road.
Southbound traffic was moving again by 5:30 a.m., but the northbound lanes weren't reopened until just before 7 a.m.
* More Bronx news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube