It happened at 8:24 a.m. Thursday in the eastbound lanes of I-287 between exits 10 and 11 in Harrison.
Police have confirmed two fatalities in the crash.
Video from NewsCopter 7 showed heavily damaged vehicles and multiple first responders on the scene.
All eastbound lanes were blocked, with traffic being diverted off at Exit 10.
This breaking news story will be updated.
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