Officials say more than 200 people were inside the building on Coster Street in the South Bronx at the time of the raid.
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The event was billed as "Rumble in the Bronx," part of an illegal fight club.
Among the charges facing the 10 organizers are illegal combat, no liquor license and loaded firearms.
Over the weekend, the Sheriff's Department also busted illegal large gatherings in Chelsea and Brooklyn.
2 parties with hundreds of attendees busted
In both incidents, police found more than 200 people partying inside.
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