Iran live updates: US blockade of Iran's Strait of Hormuz ports to begin Monday

Vice President JD Vance, leading a U.S. delegation for high-stakes talks with Iran, said the two sides have not reached a deal despite negotiations lasting some 21 hours in Islamabad, Pakistan.

"The bad news is that we have not reached an agreement," Vance said in brief remarks following the conclusion of the talks. "And I think that's bad news for Iran much more than it's bad news for the United States of America. So we go back to the United States having not come to an agreement."

When asked where the negotiations deteriorated, Vance said he wouldn't get into the full details but that the U.S. needed a firm commitment from Iran that it would not seek a nuclear weapon.

"The simple fact is we need to see an affirmative commitment that they will not seek a nuclear weapon and they will not seek the tools that would enable them to quickly achieve a nuclear weapon," Vance said. "That is the core goal of the President of the United States."

Although Vance said during his remarks that Iran's enrichment facilities have been destroyed, he said the U.S. did not see the "fundamental commitment" from the Iranians not to develop a nuclear weapon in the long term.

"I think that we were quite flexible, we were quite accommodating," Vance told reporters. "The president told us you need to come here in good faith and make your best effort to get a deal."

But he said Iran did not accept U.S. terms.

In addition to Vance, special envoy Steve Witkoff and the president's son-in-law, Jared Kushner took part in the talks.

Vance said the team communicated with President Donald Trump and other members of the Cabinet throughout the negotiation process.

-ABC News' Hannah Demissie and Emily Chang

The trilateral in-person negotiations between the U.S, Iran and Pakistan have continued into the early morning hours, according to the White House.

Asked about the state of ongoing negotiations being led by Vice President JD Vance, a senior White House official told ABC News: "15 hours and counting!"

The statement came shortly after 7:30 p.m. ET, which is 4:30 a.m. in Islamabad where the talks are taking place.

Both sides met first with Pakistani leaders before the historic sitdown Saturday, the highest level face-to-face meeting between the U.S. and Iran in 47 years.

In addition to Vance, special envoy Steve Witkoff and the president's son-in-law, Jared Kushner took part in the talks with top Iranian officials, including the speaker of the Iranian Parliament.

Speaking to reporters at the White House before leaving for Miami, President Donald Trump said he doesn't "care" what happens with Iran negotiations because "regardless what happens, we win."

"Whether we make a deal or not makes no difference to me," Trump said.

Throughout the gaggle, Trump repeatedly asserted that the United States emerges victorious, no matter the result of the ongoing negotiations in Islamabad, Pakistan.

"We'll see what happens. Look, regardless we win. Regardless what happens, we win. We totally defeated that country. And so let's see what happens. Maybe they make a deal. Maybe they don't. From the standpoint of America, we win," Trump said.

While claiming that the U.S. will open the Strait of Hormuz, the president repeated his usual criticism against other countries for their lack of assistance with the critical waterway.

"Now all we do is we'll open up the strait even though we don't use it, because we have a lot of other countries in the world that do use it, that are either afraid or weak or cheap," he said.

Asked about Iran's assets, which is a key point in the Iranian's proposal, the president sidestepped and said the U.S. is in "very deep negotiations with Iran" before repeating the assertions that the U.S. will "win regardless."

The president also repeated his claims from this morning that other countries are sending oil tankers to the U.S. to be filled with oil and gas, calling this a "beautiful thing."

"One of the things that's happening is that boats are sailing up and heading out to our country - big, beautiful tankers, and we're loading them up with oil and gas and everything else and it's pretty, beautiful thing to see," he said.

Trump also acknowledged that Iran "probably [has] a couple of mines" in the Strait of Hormuz but emphasized that the U.S. has minesweepers to combat this.

"They probably have a couple of mines in the water. We have mine sweepers out there. We're sweeping these straight. In addition to that, we're negotiating," Trump said.

-ABC News' Emily Chang

The White House confirmed that trilateral meetings between the U.S., Iran and Pakistan are ongoing on Saturday.

"Trilateral in-person negotiations are ongoing," a senior White House official said in a statement to ABC News.

The "core" U.S. delegation includes Vice President JD Vance, U.S. Special Envoy Steve Witkoff and the president's son-in-law Jared Kushner, per the press pool traveling with the vice president.

Dr. Andrew Baker, deputy national security adviser to the president and national security adviser to the vice president, and Michael Vance, special advisor to the vice president for Asian affairs, will also be in attendance as the broader U.S. delegation, according to a U.S. official.

"A full suite of U.S. experts on relevant subject areas are present in Islamabad. Additional experts are supporting from Washington," the U.S. official said, per the pool.

Trump was asked if he believes the Iranians are negotiating in good faith, responding: "I'll let you know that in a very short period of time, won't take long."

The president was also asked whether or not he is hopeful about the outcome of the talks, to which he replied "whatever," and reiterated his previous statements about the U.S. military being able to "reset."

"Whatever, otherwise we'll reset. We're ready to go," Trump reportedly said.

-ABC News' Emily Chang