District Chief of EMS for O'Hare Juan Hernandez said 20 people had been transported to local hospitals with minor injuries including bruising, scrapes and ankle injuries sustained in the evacuation of the plane.
American Airlines flight 383 bound for Miami was forced to abort takeoff at about 2:35 p.m. The pilot heard a thump and thought a tire had blown. The air traffic control tower alerted the pilot to flames. A large fire quickly consumed the plane's right-side engine and wing. Flight crew immediately stopped the plane and evacuated it using the inflatable slides on the left hand side of the aircraft.
Federal officials said the cause of the fire was "uncontained" engine failure, meaning pieces were blown out of the engine.
All 170 passengers, including flight crew, and a dog were evacuated, Chicago Deputy Fire Commissioner Timothy Sampey said.
WATCH: Officials update O'Hare plane fire
Sampey said the fire was mostly extinguished quickly, but crews are still working to put out hot spots on the plane. The plane was carrying 43,000 lbs. of fuel at the time.
"This could have been absolutely devastating if it happened later, if it happened farther. There's about a thousand variables but again, they brought the aircraft to a halt, the air tower did a great job communicating to the pilot what fire they saw and they got everybody off the plane immediately," Sampey said.
Patients were taken to hospitals including Lutheran General Hospital and Presence Resurrection.
Passenger Hector Cardenas said the plane was seconds away from taking off when he heard an explosion. Large flames and a plume of black smoke could be seen rising from the aircraft.
WATCH: Hector Cardenas describes his experience on the plane
"Within 10 or 15 seconds we would have been in the air," Cardenas said.
Sarah Ahmed was also on the flight and described the chaos in the moments after the fire broke out.
"We were almost up in the air. We were full throttle, full speed ahead and then we heard this huge bang and there's fire at the window, and so everyone on the right side of the plane got up, jumped up and they'er now on the left side of the plane. So there's a stampede at the left side. The plane comes to a screeching stop. People are yelling 'open the door, open the door!' everyone's screaming and jumping on top of each other to open the door. Within that time, I think it was seven seconds, there was now smoke in the plane and the fire is right up against the windows and it's melting the windows," Ahmed said.
WATCH: Sarah Ahmed describes her experience no the plane
Conversation between the cockpit and air traffic control revealed how quickly the situation unfolded.
"American 383 heavy stopping on the runway."
"Roger, roger. Fire."
"Do you see any smoke or fire?"
"Yeah fire off the right wing."
"Ok, send out the truck."
"American 383 can you give us any information right now?"
"Uh, standby. Chicago American 383, we're evacuating."
"American 383 roger, trucks are on the way."
Video from Tarmac at O'Hare in Chicago. Black smoke and bright flames. pic.twitter.com/sCgiHvdaQu— Michelle Malkin (@michellemalkin) October 28, 2016
In a statement, the airline said, "American Airlines is fully cooperating with the National Transportation Safety Board in its investigation of flight 383. We are operating a special flight tonight to take our customers to Miami. Twenty passengers and one flight attendant reported non-critical injuries. Several were transported to Chicago-area hospitals to be evaluated. Members of American's specially trained employee volunteer CARE Team have been mobilized and dispatched to those hospitals, and Chicago O'Hare International Airport to provide assistance for our customers, crew members and their families."
The National Transportation Safety Board have taken over the investigation. The plane will remain on the runway until the NTSB is finished with their on-site investigation.
Sampey said in his estimation it's been about eight years since an incident equivalent to this occurred at O'Hare.
One runway remains closed at O'Hare. Operations at the airport are normal. Investigators from the National Transportation Safety Board are on their way to O'Hare Airport s of 4 p.m.
ABC7 Doppler 7 MAX picked up the smoke plume from the plane fire on radar.
In another airline fire on Friday, a FedEx plane caught fire while landing at the Fort Lauderdale-Hollywood International Airport, authorities said.
The plane was arriving from Memphis shortly before 6 p.m. when the fire broke out, Broward Sheriff Fire Rescue spokesman Mike Jachles.
The pilots told authorities they believe the left landing gear collapsed on the runway. Both pilots escaped without injury.
Stay tuned to Eyewitness News and abc7NY for more on this breaking news story.