NASA is already ordering landers, rovers and drones for a sprawling moon base, less than two months after the Artemis II's record-breaking lunar flyaround.
A new crew rocketed toward the International Space Station on Friday to replace the astronauts who returned to Earth early in NASA's first medical evacuation.
Thousands of space center workers and their families gathered in the predawn chill to witness the long-awaited event, delayed for years.
Only three people remain on the orbiting laboratory.
Blue Origin will make history when it sends the first person who uses a wheelchair into space on its next mission.
Four astronauts splashed down off the coast of San Diego after hustling to the International Space Station five months ago to relieve two stuck test pilots.