The incident happened at A and D Jewelry on Southern Boulevard in the Longwood section around 11 a.m. on Sunday.
Authorities say the teens entered the store with a firearm and made off with more than $200,000 worth of jewelry, mostly gold chains, watches and diamond earrings.
They are described only as male teens.
Anyone with information in regards to this incident is asked to call Crime stoppers at 1-800-577-TIPS (8477).
