It happened around 1 p.m. at the Amazing Pharmacy on East Tremont Avenue.
Police say the victim was shot in the chest inside the business.
He was rushed to St. Barnabas Hospital, where he was pronounced dead.
The suspects fled eastbound on Tremont Avenue.
No arrests have been made, and the investigation is ongoing.
Neighbors were shocked.
"I know there was a shooting, and I don't know much about the situation, but this never happens here," area resident Leida Mendez said. "Never. In this pharmacy, everyone is peaceful...I'm shocked, and I was very concerned for them because they are good people, and I've never, never seen this happen here."
Anyone with information in regard to this incident is asked to call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782).
Separately, an officer responding to the job was involved in a minor collision.
He was taken to Jacobi Hospital in stable condition.
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