Officials said people should avoid recreational activities that could result in river water coming into contact with skin, eyes or open cuts.
Meanwhile, a CDC team going door to door in East Palestine got sick during their investigation in early March.
"They're all scientists, they're sitting up here telling us nothing is wrong," one resident said in a heated exchange with Mayor Trent Conaway. "I want you to tell me why everyone in my community is getting sick!"
Ohio Gov. Mike DeWine said 4,832 cubic yards of soil have been removed from the ground in East Palestine and about six truckloads were on the way to Michigan.
Norfolk Southern repeatedly touted their financial commitment so far to the village, now at more than $5.6 million, they said, "with more to come."
"I make $14 an hour. Where am I supposed to go?" said Audrey DeSanzo, who lives about half a mile from the derailment with her two grade-school-age children. "I don't want to be here now with my kids."