Ramirez, who raised his average Sunday from .234 to .275 with four hits, homered to left-center after Derrek Lee led off the fourth with a single off John Maine (1-2). Ramirez, who has five homers, has reached base in all 19 of the Cubs' games.
Cedeno delivered a two-out, bases-loaded single off Aaron Heilman to make it 4-1 in the eighth before Pie greeted reliever Jorge Sosa with a three-run homer to cap the Cubs' five-run eighth.
It was the first homer for Pie, who came in batting .143 and entered as a defensive replacement in the top of the eighth.
With the Cubs leading 2-0 in the sixth, New York's Endy Chavez hit a leadoff double and easily made third when Maine bunted and Cubs catcher Geovany Soto threw late to third, putting runners at the corners with no outs.
But Jose Reyes grounded to Cedeno, who stepped on the bag and was able to barely double up the speedy Reyes with his throw to first as New York's first run scored. Luis Castillo then beat out an infield single and stole second, and David Wright walked before Zambrano got Carlos Beltran on a fly to left.
Reyes made an error on Lee's grounder to the start the bottom of the eighth. Heilman hit Ramirez with a pitch and Kosuke Fukudome singled to cap a 10-pitch at-bat and load the bases. Mark DeRosa struck out and Soto popped up, but Cedeno delivered a single up the middle on a 1-2 pitch. Pie then homered to right.
Carlos Marmol pitched the eighth and Kerry Wood the ninth for the Cubs.
Maine gave up five hits and two runs in six innings with two walks and a season-high six strikeouts. Zambrano improved to 4-1 against the Mets, while Maine dropped to 0-3 in his career against the Cubs.
