Police declined to release the victim's identity.
"Our hearts, and the hearts of every educator and parent goes out to his parents, his family, his community in Rocky Hill, students and faculty of the Greater Hartford Academy of Math and Science, and the entire community," said Bruce Douglas, executive director of the Capitol Region Education Council, which operates the academy. "They will all be in our prayers. This kind of incomprehensible tragedy is always on our minds. It is something we work tirelessly to prevent."
The bus driver, a teacher and 15 other students also suffered injuries, Douglas said.
State Police Lt. J. Paul Vance said the other injuries suffered in the crash aren't considered life threatening.
The collision occurred at about 8 a.m. as the bus carrying 16 students and two adults from the academy headed to a robotics competition at Farmington High School, according to police and education officials.
Witnesses said the bus was traveling westbound when it collided with a station wagon with one occupant, Vance said. He said the cause of the crash remained under investigation.