The crash happened around 9:40 a.m. at the intersection of North Black Horse Pike and Chews Landing Road.
The view from Chopper 6 HD showed a small school bus with heavy front-end damage and a car, also heavily damaged.
Multiple firefighters and other rescuers were on the scene.
At least two injuries have been reported.
Witnesses at the scene tell Action News that the bus was carrying senior citizens.
There was no immediate word on how this crash happened.