Video from Citizen App showed flames shooting through the roof of the Holly Avenue home.
Firefighters rushed to the scene at around 3 a.m.
Four people were inside the home. Everyone was able to get out safely before firefighters arrived.
Seven firefighters sustained minor injuries, mainly bumps and bruises.
Four were transported to Staten Island University Hospital North and three to Staten Island University Hospital South.
Video from NewsCopter 7 after dawn showed extensive damage to the home.
The cause of the fire is under investigation.
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