An elderly couple was believed to be in the home on Howard Avenue when it went up in flames just before 4 a.m. Friday.
The fire broke out around 6 a.m. at a six-story building on 7th Avenue between West 22nd and 23rd streets in Chelsea.
Fifteen people were rushed to nearby hospitals. Thirteen had minor injuries, with two people were seriously injured.
Officials say the fire started at 35 Van Brunt Rd. between Cross Bay Boulevard and Dead End in Far Rockaway just after 10 p.m.
The fire broke out around 11:45 p.m. on Saturday at a home on 8th Street in Fairview.
The fire broke out around 10:20 a.m. at a home on 42nd Avenue in the Corona section, just blocks from Citi Field.