The blaze broke out at 5:30 a.m. at a home in the 300 block of St. Mary Street and soon spread to three others.
Images from Chopper 6 HD showed heavy flames shooting through the roof of one of the homes.
Multiple emergency vehicles were on the scene.
A second alarm was sounded a short time at about 5:45 a.m.
Action News is told three people have been taken to Our Lady of Lourdes Medical Center in Willingboro.
One suffered burns. The other two were being treated for smoke inhalation.