Bricks from the first and second floor of the building on Myrtle Avenue near Adelphi St. and Carlton Ave. in Fort Greene collapsed and left an apartment exposed.
Neighbors said they were worried about the crumbling retaining wall for years.
The collapse happened in Park Slope near Exit 2 around 8:30 p.m. Saturday.
Debris covered the pavement in front of the building on Avenue T in Old Mill Basin.
An estimated 381 people were injured in the quake, the General Secretariat of Communication of the Presidency of Ecuador tweeted on their official account.
Officials say the building was under demolition at the time.