The Orioles sent 13 batters to the plate in the second, their most productive inning of the season. Luke Scott and Gregg Zaun each had two of Baltimore's eight hits, and the Yankees fueled the onslaught with an error, a wild pitch and a hit batter.
Nick Markakis added a solo homer in the third, Lou Montanez hit a two-run drive in the fourth and Adam Jones connected in the eighth.
Johnny Damon, Mark Teixeira and Nick Swisher homered for the Yankees, who have lost six of seven. New York has yielded 10 runs or more in six games this season; it didn't happen for a second time last year until May 18.
Hughes (1-2) gave up eight runs, eight hits and two walks in 1 2-3 innings - the shortest start in his three-year career. His ERA swelled from 2.70 to 8.49.
Orioles starter Adam Eaton (2-3) allowed four runs, four hits and five walks in five innings.
Baltimore's second inning began with three straight singles, and a run came in on an overthrow by Swisher from right field. Hughes then hit Cesar Izturis with a pitch to load the bases, and Brian Roberts delivered a sacrifice fly before Jones doubled in a run. After Markakis got an infield hit, Huff hit an 0-2 pitch over the right-field scoreboard.
Hughes then got the second out, but Scott singled and Montanez walked before Zaun greeted Edwar Ramirez with an RBI single.
Markakis' sixth homer made it 9-0, and after Swisher hit a sacrifice fly in the fourth, Montanez connected in the bottom half to make it 11-1.
Eaton gave up successive homers to Damon and Teixeira with two outs in the fifth, then retired Rodriguez on a fly to the warning track in center. Swisher homered off Danys Baez in the sixth.
Notes: RHP Brett Tomko allowed a home run on his second pitch with New York in the 8th. His contract was purchased from Triple-A Scranton-Wilkes Barre before the game. ... Zaun had three hits and is 11 for 23 in his last seven games. ... Teixeira is 6-for-10 lifetime against Eaton with two HRs. ... New York SS Derek Jeter improved to 7 for 7 in stolen-base attempts. ... All eight of Swisher's homers have come on the road.
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