Officials say there will be no sound of an explosion, but emergency vehicles will be responding with flashing lights and sirens.
More than 800 emergency responders will participate from the city police and fire departments and the Port Authority of New York and New Jersey.
The Port Authority says the street on the north side of ground zero will be closed to all cars except the emergency vehicles in the drill.
PATH rail service will be suspended between 6 a.m. and 11:30 a.m.
The drill is expected to last about two hours.
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