The fire apparently started in a sofa in a 16th-floor hallway of 360 East 137th Street just after 1:30 a.m. Thursday.
Firefighters quickly put out the flames, but smoke spread through the 22-story apartment building.
Eyewitness News is told six police officers and four residents were treated for smoke inhalation.
The officers went to Jacobi Medical Center and two of the residents went to Lincoln Hospital.
Meanwhile, another fire started in a third-floor kitchen of 597 138th Street just after 4 a.m.
Flames spread to the fourth, fifth and sixth floors of the building.
Eyewitness News is told 18 firefighters were injured, but only two had serious injuries.
Some 20 residents were left temporarily homeless by the flames.
The cause of the fire is under investigation.
NEW YORK AND TRI-STATE AREA NEWS