Three previous Gotti trials have ended in hung juries. This jury has been deliberating in Manhattan federal court for over a week.
Deliberations will resume on Monday.
In the latest case, the government linked Gotti to a string of murders in the 1980s and 1990s and to drug trafficking. He denied the charges, claiming he quit the mob more than a decade ago.
His father died in prison while serving a life term for a 1992 murder and racketeering conviction.
