When firefighters arrived, they were met with intense flames shooting out of all of the windows.
Officials say within 20 minutes, five firefighters suffered various injuries. They were taken to Bellevue Medical Center.
Eyewitness News is told two firefighters fell and were badly hurt. They reportedly fell when a banister gave way on them. Officials say they are in serious but stable condition.
The three other firefighters were treated for less serious injuries, including minor burns and smoke inhalation.
It took hours to bring the fire under control.
The cause of the fire is under investigation.