Nassau County police say 60-year-old Kevin Roberts was driving westbound on Hempstead Turnpike when his Oldsmobile collided with an eastbound Toyota.
The impact pushed the Toyota into a Honda and then a metal pole.
The 5-year-old girl, who police say was not belted in, was ejected from the Toyota.
The driver and four other passengers in the Toyota were evaluated at a hospital. The 5 year old was listed in stable condition.
Roberts, of Franklin Square, faces aggravated driving while intoxicated and other charges when he is arraigned in Hempstead on Wednesday.