Police say 43-year-old Angelo Grimaldi of Selden was driving on Bowdoin Road at around 8 p.m. Saturday when he lost control of the vehicle and collided with a tree.
Authorities say 45-year-old Kevin Demaille of Centereach was also inside the car.
Both men were transported to Stony Brook University Medical Center where they died as a result of their injuries.
The vehicle has been impounded for a safety check.
The cause of the accident is still under investigation.
Anyone with information about this crash please call 631-854-8652 or Crime Stoppers at 1-800-220-TIPS.