The crash happened between exits 4 and 5 in Mount Laurel in Burlington County just after 10 a.m.
There were up to four vehicles involved, including two tractor trailer and two passenger vehicles.
The southbound lanes were closed for several hours before being re-opened for the afternoon rush.
Southbound NJ Turnpike traffic was being diverted off the roadway at Interchange 7A.
The cause of the crash is still being investigated.
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