He said afterward he's not sure how severe the injury is and will get re-examined Monday.
"It was frustrating," said Pierre-Paul, whose seven sacks lead the team. "Especially when I'm sitting out. It [stinks] just watching in the locker room, but it is what it is."
Pierre-Paul fell to the ground late in the first half. He was helped to his feet by teammates before walking gingerly without assistance into the locker room.
Pierre-Paul had recently taken his game to another level. He had seven tackles, three sacks, a forced fumble and a fumble returned for a touchdown en route to being named NFC Defensive Player of the Week last week.
Pierre-Paul has started all 12 games for the Giants this season. He rarely comes off the field, and came into Sunday playing by far the most snaps of any defensive lineman in the NFL with 724.
Information from The Associated Press was used in this report.