Whitlock toldWCBS-TV in New York on Wednesday that jewelry and video-game systems were taken, and that it was the second break-in at his family's apartment since late November.
The Moonachie Police Department is investigating Tuesday's incident.
"It just re-establishes that no matter where you are, no matter who you are, this can happen to you," said Whitlock, who is serving a 10-game suspension for violating the NFL policy on performance-enhancing substances.
Whitlock, 25, told WCBS-TV that he and his wife and their two young children were out for a few hours when the most recent burglary took place. Whitlock said the intruders gained access through a small window of their Bergen County residence.
"It's very disgusting, actually. It's very disheartening," Whitlock's wife, Ashley, said. "You hear about things like this that do happen, but you never think, 'Oh, this is going to happen to me.'"
"It's about to be 2017," Nikita Whitlock said. "Oppression, racism, hatred, violence, there's no need for that."
A representative for Whitlock told ESPN's Josina Anderson that the player's previous residence was also burglarized.
Sgt. Richard Behrens told ESPN that the first incident at Whitlock's current residence, which occurred over the Thanksgiving holiday, was an act of vandalism in which a door window was broken.
Whitlock's 10-game ban was for the same substance that cost him four games in 2014, according to an ESPN source. The second suspension will cost him $204,705 in salary.
Whitlock, a second-year player out of Wake Forest, was already on season-ending injured reserve with a foot injury.
Whitlock was the Giants' fullback and a key special-teams contributor last season. He also played some as a pass-rushing defensive tackle. Whitlock started five games, had a sack and finished with four special-teams tackles.
Information from ESPN'sJordan Raanan was used in this report.