Novak Djokovic maintained a healthy lead at No. 1, despite losing to Wawrinka on Sunday in the final at Roland Garros. That prevented Djokovic, for now, from completing a career Grand Slam.
It was Djokovic who beat Nadal this year, ending the Spaniard's 39-match French Open winning streak.
Wawrinka's 4-6, 6-4, 6-3, 6-4 victory in the final -- a year after he lost in the first round in Paris -- gave him a second major title. He also won the 2014 Australian Open.
No. 2 Roger Federer, No. 3 Andy Murray and No. 5 Kei Nishikori did not move in the rankings.
Serena Williams' third French Open championship and 20th Grand Slam title overall increased her margin at No. 1 in the WTA rankings.
Lucie Safarova, the runner-up in Paris, moved from No. 13 to a career-best No. 7 after reaching her first Grand Slam final. Timea Bacsinszky, who pushed an ailing Williams to three sets in the semifinals, climbed nine spots to No. 15, her top ranking.
Maria Sharapova fell from No. 2 to No. 4 after losing to Safarova in the fourth round as the defending champion.
Petra Kvitova went up two places to No. 2, while Simona Halep remained at No. 3, and Caroline Wozniacki at No. 5.
Does Nadal's loss overshadow Djokovic's win?
Pardon the Interruption's Michael Wilbon and Tony Kornheiser discuss Novak Djokovic's quarterfinal win over nine-time French Open champion Rafael Nadal.