All lanes were closed due to the accident, but they had reopened by 6 p.m. Monday.
Police say the accident was between two cars.
A woman driving a GMC Envoy was driving westbound on 78 when she may have been cut off by another vehicle.
Police say she veered off the road, into the median before ending up in the eastbound lanes where she struck a Honda Accord head on.
The male victim of the Honda was transported to an area hospital with serious injuries.
The female victim was taken to University Hospital with non-life threatening injuries.
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