The crash occurred around 6:40 a.m. Tuesday on southbound Route 29, not far from the Waterfront Park baseball stadium.
Police say the driver had to be extricated from the vehicle and was pronounced dead at the scene a short time later. But three passengers in the car were not injured.
The cause of the accident remains under investigation, and the names of the man killed and his passengers were not immediately disclosed.
The accident forced authorities to block off a stretch of the highway for several hours, but no major travel delays were reported.
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