EMS received a 911 call at 12:45 a.m. of the shooting at 994 College Avenue near 165th Street in the Morrisania section.
Two of the victims had been shot in the torso, while the other suffered a graze wound to the face.
The three were taken to St. Barnabas Hospital. One suffered life-threatening injuries. The condition of the others is still not known.
There is no word on the motive for the shooting, and police have no suspects.