The crash happened around 3:30 a.m. on Willis Avenue in the Mott Haven section.
The impact of the crash was so violent and severe that the vehicle ended up on its roof.
The victims, described as four males in their 30s, were taken to Lincoln Hospital. Two of them are in serious condition, while the other two suffered only minor injuries.
Police say it appears the driver missed a turn, then struck a pole and flipped.