The accident happened just before 4:00 p.m. near the intersection of 6th Avenue and West 41st Street.
The SUV hit the front of an MTA bus that was stopped at a red light on 6th Avenue near Bryant Park.
The SUV then continued north on 6th when it struck a light pole and overturned.
The 44-year-old driver was taken to Bellevue Hospital after going into cardiac arrest and was pronounced dead. His identity has not yet been released.
A driver and two passengers were aboard the bus. No one on the bus, sidewalks or street was hurt.