Investigators say the bus was making a left turn onto Meeker Avenue from Union Avenue in Williamsburg at about 1:30 a.m. when it hit the woman walking southbound on Union Avenue.
She was pronounced dead at Woodhull Hospital.
The victim has been identified as 21-year old Marisol Martinez of Brooklyn.
The driver of the bus remained on the scene and the accident is being investigated by the NYPD.