The unidentified victim was struck while riding westbound on the Belt Parkway at Lefferts Boulevard at around 1 a.m.
The vehicle that struck the cyclist stopped, and up to five occupants fled on foot on the highway, abandoning their vehicle at the scene.
WATCH: Raw video of Belt Parkway crash scene
Another driver stopped to help, but the victim was pronounced dead.
The victim was not carrying any identification.
E-bikes are only permitted to operate on highways with a posted speed limit of 30 mph or less. The posted speed limit on the Belt Parkway is 50 mph.
The westbound Belt Parkway was closed as police investigated.
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