The girl was one of five people in a car that collided with another vehicle at East 92nd Street and Kings Highway in East Flatbush around 1 a.m.
She was ejected from the vehicle and sustained severe leg and head injuries.
She is at Kings County Hospital in critical but stable condition.
Three other passengers in the Ford -- two 46-year-old women and one 28-year-old woman -- sustained minor injuries.
The girl's 53-year-old uncle, Marcos Portorreal, was driving the Ford.
He was charged with aggravated driving while intoxicated with a child in the car, a felony under Leandra's Law.
The 40-year-old driver of the other vehicle, Garth Morris, was charged with driving while ability impaired.
ALSO READ | Exclusive: Family speaks after boy, grandmother critically hurt in NJ hit and run
* More Brooklyn news
* Send us a news tip
* Download the abc7NY app for breaking news alerts
* Follow us on YouTube