The incident happened on 37th Ave and Main Street in Flushing.
FDNY say the fire began in a hair salon just before midnight.
It then started to spread to an adjacent three-story building.
Over 200 crew members were on scene of the seven-alarm fire that took seven-plus hours to put out.
Seven firefighters were taken to an area hospital with injuries, but they are considered non-critical.
Fire marshals will investigate the cause of the fire.
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