The incident happened on Lower Swiftwater Road near Route 611 in Pocono Township.
The woman, who has not been identified, drove over a gas line that was buried under a road, which triggered the explosion.
ALSO READ | Nashville Christmas bomber showed interest in 'lizard people' conspiracy theories, sources say
There were three other people in the car, including a 3-year-old child who survived the blast and will be OK.
A man in the car was also injured.
The company that owns the gas line says there was no indication of an explosion involving its main or associated equipment.
TRENDING NOW | Black teen accused of stealing phone in viral incident at NYC hotel says he's shell shocked
* Get Eyewitness News Delivered
* Follow us on YouTube
* More local news
* Send us a news tip
* Download the abc7NY app for breaking news alerts Submit a News Tip