The ticket blitz is set to start at midnight Tuesday.
Police officials say they expect to issue thousands of citations.
A similar blitz in March led to nearly 6,700 tickets and $800,000 in fines.
NYPD spokesman Paul Browne says police are only concerned with making the roads safer, not raising money for the cash-strapped city.
At least one study has found that people who talk on the phone while they drive are as impaired as some drunken drivers.