Israel targeted Hezbollah leader Hassan Nasrallah in a strike Friday on Beirut, according to a senior U.S. official.
At least two people were killed and 76 others were injured in the strike, according to the Lebanese Health Ministry.
Nasrallah and some of his lieutenants were in Beirut making a quick visit when the strike took place, according to the official. Israel let the U.S. know less than an hour before this strike that it was going to target Nasrallah, the official said.
It's unclear whether the strike was successful.
After speaking at the United Nations on Friday, Prime Minister Benjamin Netanyahu will fly back to Israel on Friday night, sooner than originally planned, according to his office.
"Don't let Nasrallah drag Lebanon into the abyss," Netanyahu said during his address to the U.N. an hour before the strike. "We're not at war with you. We're at war with Hezbollah, which has hijacked your country and threatens to destroy ours. As long as Hezbollah chooses the path of war, Israel has no choice. ... Israel must defeat Hezbollah"
A huge plume of smoke could be seen over a residential area of Beirut on Friday as Israel claimed it struck Hezbollah's central headquarters in the city.
"Moments ago, the Israel Defense Forces carried out a precise strike on the central headquarter of the Hezbollah terror organization that served as an epicenter of Hezbollah's terror," the IDF said in a statement, before accusing Hezbollah of intentionally building the headquarters amid civilian infrastructure.
"Hezbollah's central headquarter was intentionally built under residential buildings in the heart of the Dahia in Beirut as part of Hezbollah strategy of using Lebanese people as human shields," the IDF said.
The U.S. had no involvement or advanced warning of the Israeli strike, deputy Pentagon press secretary Sabrina Singh told reporters Friday. Defense Secretary Lloyd Austin spoke with his Israeli counterpart as the operation was "already under way," Singh said.
"This operation happened within the last few hours. We are still assessing the event, and don't have any additional information or any further specifics to provide at this time," Singh said.
Exchanges continued between Israel and Lebanon on Thursday. More than 700 people have been killed in Israeli strikes on Lebanon since Monday, according to Lebanese officials.
More than 118,000 people have been displaced in Lebanon since Monday, according to the United Nations
"The relentless airstrikes have pushed tens of thousands from the South, southern suburbs of Beirut and the Bekaa to safer locations in Beirut, Mount Lebanon, and the North," the United Nations said in a statement Friday. "Movements peaked on both Monday and Tuesday, creating congestion and chaos. They have continued more gradually as many people are still looking for homes and shelter."
A missile was fired into a Beirut neighborhood on Thursday, according to video released by the Israeli military. The strike, which hit a southern Beirut suburb, killed the head of one of Hezbollah's air force units, Mohammad Surur, according to the military.
Separately, at least 19 people were injured after a missile from Yemen's Iran-backed Houthi rebels was intercepted over central Israel late Thursday, according to Israeli authorities.
Speaking at the United Nations on Friday, Netanyahu sought to rally international support as Israeli officials say they are planning for a potential ground invasion into Lebanon.
French President Emmanuel Macron called the number of civilian victims of Israeli strikes in recent days "absolutely shocking" and called on both Israel and Hezbollah to stop attacks across the border.
France is "opposed to Lebanon becoming Gaza again," Macron said.
Reacting to Netanyahu's comments Thursday, in which the Israeli prime minister signaled he was unwilling to agree to a cease-fire, Macron said he thought those remarks were not definitive.
"We will continue our contact and close coordination with our American partners, all our mobilized partners, including Canada, and by communicating with theIsraelis ourselves, we will do everything to ensure that this proposal is accepted," Macron said.
Speaking Thursday at the United Nations General Assembly in New York, Lebanese Foreign Minister Abdallah Bou Habib renewed calls for a cease-fire in Lebanon amid concerns Israel is preparing for a ground invasion.