Two other people suffered minor injuries.
The fire broke out on the third floor at 225 East 105th Street, between 3rd and 2nd avenues.
Stay with Eyewitness News and 7Online.com for more on this developing story.
Three injured in Spanish Harlem fire
UPPER EAST SIDE One man was taken to Weill Cornell Medical Center in serious condition after he jumped out of a third-story window to escape the flames.
