The drivers of a van and an SUV collided at the intersection of New Hampshire Avenue and Pine Avenue around 7:15 p.m.
Eyewitnesses said the van was carrying workers from a nearby car rental facility.
Another van of workers saw the crash and jumped into action, trying to pull victims from the mangled vehicles.
The injured were taken to three different hospitals, including Jersey Shore Medical Center, which confirmed four victims in its trauma center.
The road was shut down for hours during the cleanup and police investigation, but it has since reopened.
Investigators are looking into what caused the crash.
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